{"id":537,"date":"2024-10-07T16:41:09","date_gmt":"2024-10-07T16:41:09","guid":{"rendered":"https:\/\/www.tepedesign.cz\/?page_id=537"},"modified":"2024-10-17T20:22:43","modified_gmt":"2024-10-17T20:22:43","slug":"trombofilni-mutace","status":"publish","type":"page","link":"https:\/\/www.znojmo-prenatal.cz\/index.php\/trombofilni-mutace\/","title":{"rendered":"Trombofiln\u00ed mutace"},"content":{"rendered":"\t\t
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Trombofiln\u00ed mutace<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Trombofiln\u00ed mutace\u00a0 (TM) \u2013 trombofilie<\/span><\/h2>

D\u011bdi\u010dn\u00e1 trombofilie je vrozen\u00fd sklon ke zv\u00fd\u0161en\u00e9mu sr\u00e1\u017een\u00ed krve. Tato vlastnost m\u016f\u017ee b\u00fdt v\u00a0n\u011bkter\u00fdch p\u0159\u00edpadech pro sv\u00e9 nositele v\u00fdhodn\u00e1 (omezen\u00ed ztr\u00e1t krve p\u0159i poran\u011bn\u00ed). Sou\u010dasn\u011b v\u0161ak m\u016f\u017ee b\u00fdt i\u00a0 p\u0159\u00ed\u010dinou r\u016fzn\u00fdch komplikac\u00ed v\u00a0t\u011bhotenstv\u00ed, p\u0159i dlouhodob\u00e9m znehybn\u011bn\u00ed\u00a0\u00a0 nebo p\u0159i\u00a0 u\u017e\u00edv\u00e1n\u00ed\u00a0 n\u011bkter\u00fdch l\u00e9k\u016f m\u016f\u017ee zp\u016fsobit hlubokou trombosu ( ucp\u00e1n\u00ed \u017e\u00edly) \u010di\u00a0 plicn\u00ed embolii. .\u00a0<\/span><\/p>

Jak\u00e9 jsou nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010diny\u00a0\u00a0 TM\u00a0 ?<\/span><\/h2>

\u2013 mutace genu pro inhibitor koagulace faktor V- tzv. Leidensk\u00e1 mutace\u00a0 (FVL)<\/span>
\u2013 mutace\u00a0 enzymu konvertuj\u00edc\u00edho kyselinu listovou \u2013 metyltetrahydrofol\u00e1tredukt\u00e1sy\u00a0\u00a0 (MTHFR)\u00a0 s n\u00e1sleduj\u00edc\u00edm zv\u00fd\u0161en\u00edm hladiny homocysteinu v krvi<\/span>
\u2013 mutace koagula\u010dn\u00edho faktoru II zvy\u0161uj\u00edc\u00edho hladinu protrombinu\u00a0 (FII)<\/span><\/p>

Leidensk\u00e1 mutace\u00a0 (FVL)<\/span><\/h2>

Jedn\u00e1 se o nej\u010dast\u011bj\u0161\u00ed vrozenou koagulopathii. Riziko trombembolie je b\u011bhem \u017eivota mezi nosi\u010di p\u0159ibli\u017en\u011b 30%. Vyskytuje se ve form\u011b\u00a0 hetorozygotn\u00ed \u2013 posti\u017een gen jen na jednom chromozomu (3-7% populace), nebo\u00a0 homozygotn\u00ed- posti\u017eeny jsou geny na obou p\u00e1rov\u00fdch chromozomech . Je-li tedy riziko\u00a0 \u017eiln\u00ed trombosy u \u010dlov\u011bka do 40 let\u00a0 1x z\u00a010\u00a0000, u nosi\u010de FVL se zvy\u0161uje na 1x\u00a0 z\u00a0750 a p\u0159i\u00a0\u00a0 u\u017e\u00edv\u00e1n\u00ed hormon\u00e1ln\u00ed\u00a0\u00a0\u00a0\u00a0 antikoncepce je toto riziko 1x z\u00a0300 u\u017eivatelek.\u00a0<\/span><\/p>

Hyperhomocysteinemie ( MTHFR)<\/span><\/h2>

\u00a0<\/strong>Zv\u00fd\u0161en\u00e1 hladina homocysteinu se projev\u00ed p\u0159i nedostatku vitamin\u016f B6, B12 a kyseliny listov\u00e9. Tato mutace je sice jednou z\u00a0nej\u010dast\u011bj\u0161\u00edch, je v\u0161ak p\u0159i\u00a0 vzniku \u017eiln\u00ed trombosy nejm\u00e9n\u011b z\u00e1va\u017en\u00e1.<\/span><\/p>

Je jednou z p\u0159\u00ed\u010din :<\/span><\/p>

– trombembolie<\/span><\/p>

– roz\u0161t\u011bpov\u00fdch\u00a0 vad u plodu<\/span><\/p>

– opakovan\u00fdch\u00a0 potrat\u016f<\/span><\/p>

– nitrod\u011blo\u017en\u00edho \u00famrt\u00ed<\/span><\/p>

– hypotrofie plodu<\/span><\/p>

– preeclampsie<\/span><\/p>

– abrupce placenty<\/span><\/p>

\u00a0<\/p>

Defekt antitrombinu\u00a0 (FII)<\/span><\/h2>

Tato porucha m\u00e1 nejsiln\u011bj\u0161\u00ed protrombotick\u00e9 \u00fa\u010dinky. Riziko rozvoje trombembolie je mezi nosi\u010di b\u011bhem \u017eivota 70-90%.\u00a0 Krom\u011b trombosy je pova\u017eov\u00e1n za jednu z\u00a0p\u0159\u00ed\u010din:<\/span>
\u2013 opakovan\u00fdch potrat\u016f<\/span>
\u2013 intrauterinn\u00edho \u00famrt\u00ed plodu\u00a0<\/span><\/p>

Pro\u010d a u koho vy\u0161et\u0159ovat:<\/span><\/h2>

\u2013 sn\u00ed\u017een\u00ed rizika\u00a0 u\u017e\u00edv\u00e1n\u00ed hormon\u00e1ln\u00ed antikoncepce<\/span>
\u2013 opakovan\u00e9 t\u011bhotensk\u00e9 ztr\u00e1ty nebo komplikace ( hypotrofie, abrupce placenty,\u00a0 preeclampsie )<\/span>
\u2013 v\u00fdskyt trombosy v rodin\u011b\u00a0<\/span><\/p>

Jak se vy\u0161et\u0159en\u00ed prov\u00e1d\u00ed ?<\/span><\/h2>

Odb\u011br\u00a0 DNA vzork\u016f k\u00a0vy\u0161et\u0159en\u00ed je mo\u017en\u00e9 prov\u00e9st z\u00a0krve nebo speci\u00e1ln\u00edm odb\u011brov\u00fdm setem ze vzorku slin z \u00a0\u00fastn\u00ed\u00a0 dutiny.\u00a0<\/span><\/p>

Jak\u00e1 je cena tohoto vy\u0161et\u0159en\u00ed?<\/span><\/h2>

Pokud je vy\u0161et\u0159en\u00ed indikov\u00e1no l\u00e9ka\u0159em, je vy\u0161et\u0159en\u00ed hrazeno ze v\u0161eobecn\u00e9ho zdravotn\u00edho poji\u0161t\u011bn\u00ed. U vy\u0161et\u0159en\u00ed na vlastn\u00ed \u017e\u00e1dost \u2013 viz cen\u00edk .\u00a0<\/span><\/p>

Vy\u0161et\u0159en\u00ed na vlastn\u00ed \u017e\u00e1dost<\/span><\/h2>

\u00a0<\/strong>V\u0161echna n\u00e1mi prov\u00e1d\u011bn\u00e1 vy\u0161et\u0159en\u00ed si lze objednat i bez doporu\u010den\u00ed Va\u0161eho o\u0161et\u0159uj\u00edc\u00edho l\u00e9ka\u0159e. V\u00a0t\u011bchto p\u0159\u00edpadech v\u0161ak tato vy\u0161et\u0159en\u00ed nejsou propl\u00e1cena\u00a0 z\u00a0v\u0161eobecn\u00e9ho zdravotn\u00edho poji\u0161t\u011bn\u00ed.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Trombofiln\u00ed mutace Trombofiln\u00ed mutace\u00a0 (TM) \u2013 trombofilie D\u011bdi\u010dn\u00e1 trombofilie je vrozen\u00fd sklon ke zv\u00fd\u0161en\u00e9mu sr\u00e1\u017een\u00ed krve. Tato vlastnost m\u016f\u017ee b\u00fdt […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-537","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/pages\/537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/comments?post=537"}],"version-history":[{"count":14,"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/pages\/537\/revisions"}],"predecessor-version":[{"id":1532,"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/pages\/537\/revisions\/1532"}],"wp:attachment":[{"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/media?parent=537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}