{"id":531,"date":"2024-10-07T16:40:21","date_gmt":"2024-10-07T16:40:21","guid":{"rendered":"https:\/\/www.tepedesign.cz\/?page_id=531"},"modified":"2024-10-17T20:19:20","modified_gmt":"2024-10-17T20:19:20","slug":"trisomy-nipt","status":"publish","type":"page","link":"https:\/\/www.znojmo-prenatal.cz\/index.php\/trisomy-nipt\/","title":{"rendered":"Trisomy NIPT"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"531\" class=\"elementor elementor-531\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ae610d e-flex e-con-boxed e-con e-parent\" data-id=\"7ae610d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d4382b8 elementor-widget elementor-widget-spacer\" data-id=\"d4382b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d17298f elementor-widget elementor-widget-spacer\" data-id=\"d17298f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55b21aa elementor-widget elementor-widget-spacer\" data-id=\"55b21aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91a8562 elementor-widget elementor-widget-heading\" data-id=\"91a8562\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Trisomy NIPT<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a60b1b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1a60b1b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b83f606 elementor-widget elementor-widget-spacer\" data-id=\"b83f606\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ddf9489 e-flex e-con-boxed e-con e-parent\" data-id=\"ddf9489\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-260be18 elementor-widget elementor-widget-text-editor\" data-id=\"260be18\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1 style=\"text-align: center;\"><span style=\"color: #000000;\">Trisomy NIPT<\/span><\/h1><h3 style=\"text-align: center;\"><span style=\"color: #000000;\">( Non Invasive Prenatal Testing )<\/span><\/h3><p style=\"text-align: center;\"><span style=\"color: #000000;\">Na\u0161e laborato\u0159 jako jedna z prvn\u00edch v \u010cesk\u00e9 republice zvl\u00e1dla neinvaz\u00edvn\u00ed prenat\u00e1ln\u00ed test trisomie (NIPT)\u00a0 \u2013 Downova syndromu,\u00a0 Edwardsova syndromu a\u00a0 Patauova syndromu u plodu z krve matky .<\/span><\/p><h3 style=\"text-align: center;\"><span style=\"color: #000000;\"><b>Metodika<\/b><\/span><\/h3><p style=\"text-align: center;\"><span style=\"color: #000000;\">Do krve matky se od za\u010d\u00e1tku t\u011bhotenstv\u00ed uvol\u0148uj\u00ed z placenty voln\u00e9 fragmenty DNA. Tyto fragmenty je mo\u017en\u00e9 modern\u00ed technikou NGS (sekvenov\u00e1n\u00ed nov\u00e9 generace) vy\u0161et\u0159it. Analyzuj\u00ed se \u0159\u00e1dov\u011b miliony voln\u00fdch fragment\u016f DNA v mate\u0159sk\u00e9 krvi. Relativn\u00ed \u010detnost fragment\u016f se hodnot\u00ed bioinformatickou analysou se stanoven\u00edm z-score. Trisomie je vysoce pravd\u011bpodobn\u00e1 p\u0159i statisticky v\u00fdznamn\u00e9m zv\u00fd\u0161en\u00ed \u010detnosti fragment\u016f z ur\u010dit\u00e9ho chromozomu.<\/span><\/p><h3 style=\"text-align: center;\"><span style=\"color: #000000;\"><b>Efektivita<\/b><\/span><\/h3><p style=\"text-align: center;\"><span style=\"color: #000000;\">Tato opakovan\u011b validovan\u00e1 metoda vy\u0161et\u0159en\u00ed voln\u00e9 DNA plodu v krvi matky diagnostikuje trizomie chromozom\u016f \u010d. 21, 18 a 13 plodu se senzitivitou nad 99 %. Spolehlivost zji\u0161t\u011bn\u00ed trisomie 21, 18, 13 je srovnateln\u00e1 s invasivn\u00edmi metodami vy\u0161et\u0159en\u00ed plodu . Pozitivn\u00ed v\u00fdsledek je nutn\u00e9 je\u0161t\u011b ov\u011b\u0159it pomoc\u00ed invazivn\u00edho vy\u0161et\u0159en\u00ed.<\/span><\/p><h3 style=\"text-align: center;\"><span style=\"color: #000000;\"><b>Indikace<\/b><\/span><\/h3><p style=\"text-align: center;\"><span style=\"color: #000000;\">Trisomy\u00a0 m\u016f\u017ee b\u00fdt indikov\u00e1n po 12. t\u00fddnu t\u011bhotenstv\u00ed p\u0159i :<\/span><\/p><p style=\"text-align: center;\"><span style=\"color: #000000;\">&#8211; Zv\u00fd\u0161en\u00e9m riziku trisomie chromozomu \u010d.21 ,13 a 18<\/span><\/p><p style=\"text-align: center;\"><span style=\"color: #000000;\">\u00a0&#8211; Atypick\u00e9m v\u00fdsledku screeningu s hrani\u010dn\u00edm rizikem.<\/span><\/p><p style=\"text-align: center;\"><span style=\"color: #000000;\">&#8211; V\u011bku nad 35 let.<\/span><\/p><p style=\"text-align: center;\"><span style=\"color: #000000;\">&#8211; Obav\u00e1ch o osud gravidity.<\/span><\/p><p style=\"text-align: center;\"><span style=\"color: #000000;\">&#8211; Suspektn\u00ed rodinn\u00e9 anamnese.<\/span><\/p><h3 style=\"text-align: center;\"><span style=\"color: #000000;\"><b>Limitace testu<\/b><\/span><\/h3><p style=\"text-align: center;\"><span style=\"color: #000000;\">Trisomie jsou p\u0159\u00ed\u010dinou pouze 1 % vrozen\u00fdch vad u novorozenc\u016f, tak\u017ee Trisomy NIPT) nen\u00ed univerz\u00e1ln\u00ed prenat\u00e1ln\u00ed test k vylou\u010den\u00ed v\u0161ech vrozen\u00fdch v\u00fdvojov\u00fdch vad ( roz\u0161t\u011bpy, srde\u010dn\u00ed vady, v\u00fdvoj mozku\u2026). V\u00fdsledky tohoto testu mohou b\u00fdt zkresleny chromozom\u00e1ln\u00ed aberac\u00ed matky, n\u00edzkou fet\u00e1ln\u00ed frakc\u00ed, mozaika u plodu. Test nen\u00ed vhodn\u00fd do 6 m\u011bs\u00edc\u016f po transfuzi nebo po transplantaci kmenov\u00fdch bun\u011bk.<\/span><br \/><span style=\"color: #000000;\">V ur\u010dit\u00e9 \u010d\u00e1sti vzork\u016f (v \u0159\u00e1du procent) nen\u00ed mo\u017en\u00e9 vy\u0161et\u0159en\u00ed zhodnotit a test je nutn\u00e9 opakovat!<\/span><\/p><h3 style=\"text-align: center;\"><span style=\"color: #000000;\"><b>Organizace vy\u0161et\u0159en\u00ed:<\/b><\/span><\/h3><p style=\"text-align: center;\"><span style=\"color: #000000;\">Odb\u011br krve na vy\u0161et\u0159en\u00ed Trisomy\u00a0 je prov\u00e1d\u011bn nejl\u00e9pe po objedn\u00e1n\u00ed v Centru prenat\u00e1ln\u00ed diagnostiky. Sou\u010d\u00e1st\u00ed tohoto vy\u0161et\u0159en\u00ed je pohovor s klinick\u00fdm genetikem, kter\u00fd je\u0161t\u011b zv\u00e1\u017e\u00ed vhodnost tohoto vy\u0161et\u0159en\u00ed a interpretuje v\u00fdsledky. V cen\u011b tohoto vy\u0161et\u0159en\u00ed je zahrnuto i pe\u010dliv\u00e9 ultrazvukov\u00e9 vy\u0161et\u0159en\u00ed v den odb\u011bru zam\u011b\u0159en\u00e9 na ev. markery chromozom\u00e1ln\u00edch aberac\u00ed.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Trisomy NIPT Trisomy NIPT ( Non Invasive Prenatal Testing ) Na\u0161e laborato\u0159 jako jedna z prvn\u00edch v \u010cesk\u00e9 republice zvl\u00e1dla [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-531","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/pages\/531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/comments?post=531"}],"version-history":[{"count":10,"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/pages\/531\/revisions"}],"predecessor-version":[{"id":1369,"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/pages\/531\/revisions\/1369"}],"wp:attachment":[{"href":"https:\/\/www.znojmo-prenatal.cz\/index.php\/wp-json\/wp\/v2\/media?parent=531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}